Our mission is to provide the highest quality treatments, products and testing to promote

                   optimal health, beauty and longevity in a non-pharmaceutical environment
              Researched by The  Anti-Aging Clinic   "Aging Younger "            
 

HOME        
 
Skincare 
  
                    
 Vitamins
   
                    
 Hormones  
                    
 Water        
                    
 Detox         
                    
 Growth  
 Factor
 
       
                    
 Services     
   
 
Blog 

Aging
Younger
Natural Health

    

       
 QUESTIONS 
    
 TESTING   
      
 BadHabits  
             
 Disclaimer 

 Contact

 

                   Prostate, Fenugreek Case Study

BACK to questions

Prostate Cancer Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, USA.

"In recent years, various dietary components that can potentially be used for the prevention and treatment of cancer have been identified. In this study, we demonstrate that extract (FE) from the seeds of the plant Trigonella foenum graecum, commonly called fenugreek, are cytotoxic in vitro to a panel of cancer but not normal cells. Treatment with 10-15 ug/mL of FE for 72 h was growth inhibitory to breast, pancreatic and prostate cancer cell lines (PCa). When tested at higher doses (15-20 ug/mL), FE continued to be growth inhibitory to PCa cell lines but not to either primary prostate or hTert-immortalized prostate cells. At least part of the growth inhibition is due to induction of cell death, as seen by incorporation of Ethidium Bromide III into cancer cells exposed to FE. Molecular changes induced in PCa cells are: in DU-145 cells: downregulation of mutant p53, and in PC-3 cells upregulation of p21 and inhibition of TGFbeta induced phosphorylation of Akt. The surprising finding of our studies is that death of cancer cells occurs despite growth stimulatory pathways being simultaneously upregulated (phosphorylated) by FE. Thus, these studies add another biologically active agent to our armamentarium of naturally occurring agents with therapeutic potential".